Co-authored by our MA PMHC Bundle Lead, Dr. Tiffany Moore Simas, this Clinical Practice Update provides revised guidance on the use of both Zuranolone and Brexanolone for management of Postpartum Depression with onset in the third trimester or within four weeks postartum. This update was released in October 2025.

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Additional, relevant, ACOG Clinical Practice Guidelines for PMHC Management:

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